Article
Genome-wide association study of bronchopulmonary dysplasia: a potential role for variants near the CRP gene.
Scientific reports - 24 Aug 2017
Mahlman Mari, Karjalainen Minna K, Huusko Johanna M, Andersson Sture, Kari M Anneli, Tammela Outi K T, Sankilampi Ulla, Lehtonen Liisa, Marttila Riitta H, Bassler Dirk, Poets Christian F, Lacaze-Masmonteil Thierry, Danan Claude, Delacourt Christophe, Palotie Aarno, Muglia Louis J, Lavoie Pascal M, Hadchouel Alice, Rämet Mika, Hallman Mikko
Abstract excerpt
Bronchopulmonary dysplasia (BPD), the main consequence of prematurity, has a significant heritability, but little is known about predisposing genes. The aim of this study was to identify gene loci predisposing infants to BPD. The initial genome-wide association study (GWAS) included 174 Finnish preterm infants of gestational age 24-30 weeks. Thereafter, the most promising single-nucleotide polymorphisms (SNPs)...
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