Article
Prevalence and clinical association of MET gene overexpression and amplification in patients with NSCLC: Results from the European Thoracic Oncology Platform (ETOP) Lungscape project.
Lung cancer (Amsterdam, Netherlands) - 1 Sept 2017
Bubendorf Lukas, Dafni Urania, Schöbel Martin, Finn Stephen P, Tischler Verena, Sejda Aleksandra, Marchetti Antonio, Thunnissen Erik, Verbeken Eric K, Warth Arne, Sansano Irene, Cheney Richard, Speel Ernst Jan M, Nonaka Daisuke, Monkhorst Kim, Hager Henrik, Martorell Miguel, Savic Spasenija, Kerr Keith M, Tan Qiang, Tsourti Zoi, Geiger Thomas R, Kammler Roswitha, Schulze Katja, Das-Gupta Ashis, Shames David, Peters Solange, Stahel Rolf A
Abstract excerpt
INTRODUCTION: In a well-defined NSCLC cohort of the ETOP Lungscape program, we explored the epidemiology of IHC MET overexpression and amplification, their inter-correlation, and their association to outcome. METHODS: Resected NSCLC were assessed for MET gene copy number (GCN) and expression using silver in-situ hybridization (SISH) and immunohistochemistry (IHC) on TMAs in a multicenter setting. MET...
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