Article
Whole Exome Sequencing Identified a Novel IGFBP6 Variant in a Disc Degeneration Pedigree.
Genetic testing and molecular biomarkers - 1 Oct 2017
Fu Sun, Lei Wang, Lanlan Dai, Qi-Ling Yuan, Liang Liu, Hanlin Zhou, Jianguo Zhang, Yin-Gang Zhang
Abstract excerpt
OBJECTIVE: To identify the likely causal mutation that results in disc degeneration in a pedigree with a high incidence of disc degeneration. MATERIALS AND METHODS: A large pedigree with a high incidence of disc degeneration was recruited for this study. Exome sequencing was completed on four family members with disc degeneration to screen for potential causal gene variants. Detected variants were filtered...
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