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Article

A multi-parametric analysis of Trypanosoma cruzi infection: common pathophysiologic patterns beyond extreme heterogeneity of host responses.

Scientific reports - 21 Aug 2017

Santi-Rocca Julien, Fernandez-Cortes Fernando, Chillón-Marinas Carlos, González-Rubio María-Luisa, Martin David, Gironès Núria, Fresno Manuel

Abstract excerpt

The extreme genetic diversity of the protozoan Trypanosoma cruzi has been proposed to be associated with the clinical outcomes of the disease it provokes: Chagas disease (CD). To address this question, we analysed the similarities and differences in the CD pathophysiogenesis caused by different parasite strains. Using syngeneic mice infected acutely or chronically with 6 distant parasite strains, we integrated...

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Identifiers

PMID: 28827716
DOI: 10.1038/s41598-017-08086-8
PMCID: PMC5566495

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