Article
Cross-phenotype association mapping of the MHC identifies genetic variants that differentiate psoriatic arthritis from psoriasis.
Annals of the rheumatic diseases - 1 Oct 2017
Bowes John, Ashcroft James, Dand Nick, Jalali-Najafabadi Farideh, Bellou Eftychia, Ho Pauline, Marzo-Ortega Helena, Helliwell Philip S, Feletar Marie, Ryan Anthony W, Kane David J, Korendowych Eleanor, Simpson Michael A, Packham Jonathan, McManus Ross, Brown Matthew A, Smith Catherine H, Barker Jonathan N, McHugh Neil, FitzGerald Oliver, Warren Richard B, Barton Anne
Abstract excerpt
OBJECTIVES: Psoriatic arthritis (PsA) is a chronic inflammatory arthritis, with a strong heritable component, affecting patients with psoriasis. Here we attempt to identify genetic variants within the major histocompatibility complex (MHC) that differentiate patients with PsA from patients with cutaneous psoriasis alone (PsC). METHODS: 2808 patients with PsC, 1945 patients with PsA and 8920 population controls...
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