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Article

Importance of PCR-based Tumor Testing in the Evaluation of Lynch Syndrome-associated Endometrial Cancer.

Advances in anatomic pathology - 1 Nov 2017

Bruegl Amanda S, Kernberg Annessa, Broaddus Russell R

Abstract excerpt

Lynch syndrome (LS) is a hereditary cancer syndrome caused by a germline mutation in a DNA mismatch repair gene, usually MLH1, MSH2, MSH6, or PMS2. The most common cancers associated with LS are colorectal adenocarcinoma and endometrial carcinoma. Identification of women with LS-associated endometrial cancer is important, as these women and their affected siblings and children are at-risk of developing these same...

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Topics

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Share to Colorectal Neoplasms, Hereditary Nonpolyposis
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Early Detection of Cancer

Share to Endometrial Neoplasms

Share to Immunohistochemistry

Share to Microsatellite Instability

Share to Predictive Value of Tests

Share to Reproducibility of Results

Source

Open in PubMed Open full text

Identifiers

PMID: 28820751
DOI: 10.1097/PAP.0000000000000169
PMCID: PMC5657565

Genes

MLH1
MSH2
MSH6
PMS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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