Article
Use of biological priors enhances understanding of genetic architecture and genomic prediction of complex traits within and between dairy cattle breeds.
BMC genomics - 10 Aug 2017
Fang Lingzhao, Sahana Goutam, Ma Peipei, Su Guosheng, Yu Ying, Zhang Shengli, Lund Mogens Sandø, Sørensen Peter
Abstract excerpt
BACKGROUND: A better understanding of the genetic architecture underlying complex traits (e.g., the distribution of causal variants and their effects) may aid in the genomic prediction. Here, we hypothesized that the genomic variants of complex traits might be enriched in a subset of genomic regions defined by genes grouped on the basis of "Gene Ontology" (GO), and that incorporating this independent biological...
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