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Article

Caveolin 1 restricts Group AStreptococcusinvasion of nonphagocytic host cells

4 Aug 2017

Abstract excerpt

Caveolae are composed of 2 major proteins, caveolin 1 (CAV1) and cavin 1 or polymerase transcript release factor I (CAVIN1). Here, we demonstrate that CAV1 levels modulate invasion of Group A Streptococcus (GAS) into nonphagocytic mammalian cells. GAS showed enhanced internalisation into CAV1-knockout mouse embryonic fibroblasts and CAV1 knockdown human epithelial HEp-2 cells, whereas overexpression of CAV1 in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 28778116
DOI: 10.1111/cmi.12772

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