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Article

Reverse Engineering Field Isolates of Myxoma Virus Demonstrates that Some Gene Disruptions or Losses of Function Do Not Explain Virulence Changes Observed in the Field.

Journal of virology - 15 Oct 2017

Liu June, Cattadori Isabella M, Sim Derek G, Eden John-Sebastian, Holmes Edward C, Read Andrew F, Kerr Peter J

Abstract excerpt

The coevolution of myxoma virus (MYXV) and wild European rabbits in Australia and Europe is a paradigm for the evolution of a pathogen in a new host species. Genomic analyses have identified the mutations that have characterized this evolutionary process, but defining causal mutations in the pathways from virulence to attenuation and back to virulence has not been possible. Using reverse genetics, we examined the...

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Identifiers

PMID: 28768866
DOI: 10.1128/JVI.01289-17
PMCID: PMC5625522

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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