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Forkhead Box M1 positively regulates UBE2C and protects glioma cells from autophagic death

2 Aug 2017

Abstract excerpt

Ubiquitin-conjugating enzyme E2C (UBE2C) is characterized as a crucial molecule in cancer cell growth that plays an essential role in the development of gliomas, but the detailed mechanisms have not been fully elucidated. In this study, we found that Forkhead box transcription factor M1 (FoxM1) overexpression increased UBE2C expression, whereas FoxM1 suppression inhibited UBE2C expression in glioma cells. In...

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PMID: 28767320
DOI: 10.1080/15384101.2017.1356507

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