Article
Immunohistochemical detection of C9orf72 protein in frontotemporal lobar degeneration and motor neurone disease: patterns of immunostaining and an evaluation of commercial antibodies.
Amyotrophic lateral sclerosis & frontotemporal degeneration - 1 Feb 2018
Davidson Yvonne S, Robinson Andrew C, Rollinson Sara, Pickering-Brown Stuart, Xiao Shangxi, Robertson Janice, Mann David M A
Abstract excerpt
We have employed as 'gold standards' two in-house, well-characterised and validated polyclonal antibodies, C9-L and C9-S, which detect the longer and shorter forms of C9orf72, and have compared seven other commercially available antibodies with these in order to evaluate the utility of the latter as credible tools for the demonstration of C9orf72. C9-L and C9-S antibodies immunostained cytoplasmic 'speckles', and...
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