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Article

Defective ATP breakdown activity related to an ENTPD1 gene mutation demonstrated using 31P NMR spectroscopy.

Chemical communications (Cambridge, England) - 10 Aug 2017

Nardi-Schreiber Atara, Sapir Gal, Gamliel Ayelet, Kakhlon Or, Sosna Jacob, Gomori J Moshe, Meiner Vardiella, Lossos Alexander, Katz-Brull Rachel

Abstract excerpt

The ecto-nucleoside triphosphate diphosphohydrolase-1 (E-NTPDase-1, CD39) enzyme is responsible for the breakdown of extracellular ATP to ADP and then to AMP by a two-step process. Defective CD39 activity has been described in a variety of medical conditions including malignancy and rheumatic diseases and has been proved to be of major diagnostic and clinical importance. Here we show for the first time that a 31P...

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Identifiers

PMID: 28759073
DOI: 10.1039/c7cc00426e

Genes

ENTPD1

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Defective ATP breakdown activity related to an ENTPD1 gene mutation demonstrated using 31P NMR spectroscopy.PMID 28759073Read ↗

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