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Association Between Autophagy and Neurodegenerative Diseases

22 May 2018

Abstract excerpt

Autophagy is a phylogenetically conserved mechanism that controls the degradation of subcellular constituents, including misfolded proteins, and damaged organelles. The progression of many neurodegenerative diseases is thought to be driven by the aggregation of misfolded proteins; therefore, autophagic activity is thought to affect disease severity to some extent. In some neurodegenerative diseases, the...

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PMID: 29872373
DOI: 10.3389/fnins.2018.00255

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