Article
Novel approach for selective reduction of NNN in cigarette tobacco filler and mainstream smoke.
Regulatory toxicology and pharmacology : RTP - 1 Oct 2017
Lusso M, Gunduz I, Kondylis A, Jaccard G, Ruffieux L, Gadani F, Lion K, Adams A, Morris W, Danielson T, Warek U, Strickland J
Abstract excerpt
Research conducted during past decades to reduce the level of the tobacco specific nitrosamine N-nitrosonornicotine (NNN) and its precursor nornicotine in tobacco yielded identification of three tobacco genes encoding for cytochrome P450 nicotine demethylases converting nicotine to nornicotine. We carried out trials to investigate the effect of using tobaccos containing three non-functional nicotine demethylase...
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