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Article

Chemical, physical, and in vitro characterization of research cigarettes containing denicotinized tobacco.

Regulatory toxicology and pharmacology : RTP - 1 Aug 2016

Coffa Bonnie G, Coggins Christopher R E, Werley Michael S, Oldham Michael J, Fariss Marc W

Abstract excerpt

The use of very low nicotine tobacco cigarettes is currently being investigated as a possible harm reduction strategy. Here, we report the smoke chemistry, toxicity, and physical characteristics of very low nicotine cigarettes that were made using blended tobacco processed through a supercritical CO2 fluid extraction, which resulted in elimination of 96% of nicotine content (denicotinized (denic) tobacco). Three...

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Identifiers

PMID: 27181452
DOI: 10.1016/j.yrtph.2016.05.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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