Article
Peptide Nucleic Acids as miRNA Target Protectors for the Treatment of Cystic Fibrosis.
Molecules (Basel, Switzerland) - 8 Jul 2017
Zarrilli Federica, Amato Felice, Morgillo Carmine Marco, Pinto Brunella, Santarpia Giuliano, Borbone Nicola, D'Errico Stefano, Catalanotti Bruno, Piccialli Gennaro, Castaldo Giuseppe, Oliviero Giorgia
Abstract excerpt
Cystic Fibrosis (CF) is one of the most common life shortening conditions in Caucasians. CF is caused by mutations in the CF Transmembrane Conductance Regulator (CFTR) gene which result in reduced or altered CFTR functionality. Several microRNAs (miRNAs) downregulate the expression of CFTR, thus causing or exacerbating the symptoms of CF. In this context, the design of anti-miRNA agents represents a valid...
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