Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Somatic mutations in ZFHX4 gene are associated with poor overall survival of Chinese esophageal squamous cell carcinoma patients.

Scientific reports - 10 Jul 2017

Qing Tao, Zhu Sibo, Suo Chen, Zhang Lei, Zheng Yuanting, Shi Leming

Abstract excerpt

Recent genome-sequencing studies have revealed dozens of genes frequently mutated in esophageal squamous cell carcinoma, but few genes are associated with patients' clinical outcomes. Novel prognostic biomarkers are urgently needed in the clinic. We collected both somatic mutations and clinical information of 442 Chinese esophageal squamous cell carcinoma patients from four published studies. Survival analysis...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Movement
Share to Databases, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Esophageal Neoplasms

Share to Esophageal Squamous Cell Carcinoma

Share to Gene Expression Regulation, Neoplastic

Share to Homeodomain Proteins

Share to Survival Analysis

Share to Up-Regulation

Source

Open in PubMed Open full text

Identifiers

PMID: 28694483
DOI: 10.1038/s41598-017-04221-7
PMCID: PMC5504002

Genes

ZFHX4
DNAH5
KCNH7
NRXN1
SPHKAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Somatic mutations in ZFHX4 gene are associated with poor overall survival of Chinese esophageal squamous cell carcinoma patients.PMID 28694483Read ↗

Genomic analyses reveal mutational signatures and frequently altered genes in esophageal squamous cell carcinoma.Semantic proximity Read ↗

The Clinical Significance of Forkhead Box M1 in Esophageal Squamous Cell Carcinoma Tissues: A Study Based on In-house Immunohistochemistry, RNA-sequencing, and Data MiningSemantic proximity Read ↗

DNA hypermethyation and silencing ofPITX1correlated with advanced stage and poor postoperative prognosis of esophageal squamous cell carcinomaSemantic proximity Read ↗

The Genome Stability-Related lncRNA ZFPM2-AS1 Promotes Tumor Progression via miR-3065-5p/XRCC4 in Hepatocellular CarcinomaSemantic proximity Read ↗

The detective, prognostic, and predictive value of DNA methylation in human esophageal squamous cell carcinomaSemantic proximity Read ↗

Genomic analyses reveal SCN7A is associated with the prognosis of esophageal squamous cell carcinoma.Semantic proximity Read ↗

LHX2 Enhances the Malignant Phenotype of Esophageal Squamous Cell Carcinoma by Upregulating the Expression of SERPINE2.Semantic proximity Read ↗

A bioinformatics analysis: ZFHX4 is associated with metastasis and poor survival in ovarian cancerSemantic proximity Read ↗

Systematic Investigation of the Clinical Significance and Prognostic Value of the CBXs in Esophageal CancerSemantic proximity Read ↗

Decreased ZNF750 promotes angiogenesis in a paracrine manner via activating DANCR/miR-4707-3p/FOXC2 axis in esophageal squamous cell carcinomaSemantic proximity Read ↗

Aberrant DNA methylation of PAX1, SOX1 and ZNF582 genes as potential biomarkers for esophageal squamous cell carcinomaSemantic proximity Read ↗

ZNF750 is a lineage-specific tumour suppressor in squamous cell carcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.