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Article

Endothelial Hey2 deletion reduces endothelial-to-mesenchymal transition and mitigates radiation proctitis in mice.

Scientific reports - 10 Jul 2017

Mintet Elodie, Lavigne Jérémy, Paget Vincent, Tarlet Georges, Buard Valérie, Guipaud Olivier, Sabourin Jean-Christophe, Iruela-Arispe Maria-Luisa, Milliat Fabien, François Agnès

Abstract excerpt

The current study evaluated the role of Hey2 transcription factor in radiation-induced endothelial-to-mesenchymal transition (EndoMT) and its impact on radiation-induced tissue damage in mice. Phenotypic modifications of irradiated, Hey2 siRNA- and Hey2 vector plasmid-transfected human umbilical vein endothelial cells (HUVECs) resembling EndoMT were monitored by qPCR, immunocytochemistry and western blots....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28694461
DOI: 10.1038/s41598-017-05389-8
PMCID: PMC5503994

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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