Article
Whole exome sequencing identified a novel zinc-finger gene ZNF141 associated with autosomal recessive postaxial polydactyly type A.
Journal of medical genetics - 1 Jan 2013
Kalsoom Umm-e-, Klopocki Eva, Wasif Naveed, Tariq Muhammad, Khan Saadullah, Hecht Jochen, Krawitz Peter, Mundlos Stefan, Ahmad Wasim
Abstract excerpt
BACKGROUND: Postaxial polydactyly (PAP) type A is characterised by well-formed functionally developed 5th digit duplication in hands and/or feet. It is genetically heterogeneous condition, inherited both in autosomal recessive and dominant manners. To date one autosomal recessive and four autosomal dominant loci have been mapped on human chromosomes. In the present study we have investigated a consanguineous...
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