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Article

Altering equine corneal fibroblast differentiation through Smad gene transfer

6 Jul 2017

Abstract excerpt

OBJECTIVE: To explore the impact of equine corneal fibroblast (ECF) to myofibroblast (ECM) differentiation by altering the expression of the Smad genes either individually or in combination. Specifically, we sought to examine the ECF differentiation after (a) silencing of Smad2, 3, and 4 profibrotic genes individually and (b) overexpression of antifibrotic Smad7 gene and in a combination with pro- and...

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PMID: 28685927
DOI: 10.1111/vop.12485

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