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Differential Antagonism of Human Innate Immune Responses by Tick-BornePhlebovirusNonstructural Proteins

28 Jun 2017

Abstract excerpt

genus. Heartland virus (HRTV) and SFTS virus (SFTSV) were found to cause severe disease in humans, unlike other documented tick-borne phleboviruses such as Uukuniemi virus (UUKV). Phleboviruses encode nonstructural proteins (NSs) that enable them to counteract the human innate antiviral defenses. We assessed how these proteins interacted with the innate immune system. We found that UUKV NSs engaged with innate...

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PMID: 28680969
DOI: 10.1128/msphere.00234-17

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