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Article

A molecular hypothesis to explain direct and inverse co-morbidities between Alzheimer's Disease, Glioblastoma and Lung cancer.

Scientific reports - 30 Jun 2017

Sánchez-Valle Jon, Tejero Héctor, Ibáñez Kristina, Portero José Luis, Krallinger Martin, Al-Shahrour Fátima, Tabarés-Seisdedos Rafael, Baudot Anaïs, Valencia Alfonso

Abstract excerpt

Epidemiological studies indicate that patients suffering from Alzheimer's disease have a lower risk of developing lung cancer, and suggest a higher risk of developing glioblastoma. Here we explore the molecular scenarios that might underlie direct and inverse co-morbidities between these diseases. Transcriptomic meta-analyses reveal significant numbers of genes with inverse patterns of expression in Alzheimer's...

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Identifiers

PMID: 28667284
DOI: 10.1038/s41598-017-04400-6
PMCID: PMC5493619

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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