Article
A structural variant in the 5'-flanking region of the TWIST2 gene affects melanocyte development in belted cattle.
PloS one - 1 Jan 2017
Awasthi Mishra Nivedita, Drögemüller Cord, Jagannathan Vidhya, Keller Irene, Wüthrich Daniel, Bruggmann Rémy, Beck Julia, Schütz Ekkehard, Brenig Bertram, Demmel Steffi, Moser Simon, Signer-Hasler Heidi, Pieńkowska-Schelling Aldona, Schelling Claude, Sande Marcos, Rongen Ronald, Rieder Stefan, Kelsh Robert N, Mercader Nadia, Leeb Tosso
Abstract excerpt
Belted cattle have a circular belt of unpigmented hair and skin around their midsection. The belt is inherited as a monogenic autosomal dominant trait. We mapped the causative variant to a 37 kb segment on bovine chromosome 3. Whole genome sequence data of 2 belted and 130 control cattle yielded only one private genetic variant in the critical interval in the two belted animals. The belt-associated variant was a...
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