Article
[Mutations in the BCR-ABL1 gene in a peruvian patient with acute lymphoblastic leukemia resistant to therapy].
Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina) - 1 Jan 2017
Ortiz Cesar A, Alvarez Yubell P, Dongo-Pflucker Kenny L, Valdivia Emilio, Mendoza Fernández Julio, Dávila Silvia, Mora-Alférez Pamela
Abstract excerpt
CONTEXT: The fusion gene BCR-ABL1 is present in at least the fourth part of B-cell acute lymphoblastic leukemia adult cases. Patients with this fusion gene are candidates to tyrosine kinase inhibitors treatment, and the response to this therapy can be measure by quantification of BCR-ABL1 transcripts. Some patients relapse because the presence of mutations in the tyrosine kinase domain of BCR-ABL1. CASE REPORT:...
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