Article
A genetic variant near GATA3 implicated in inherited susceptibility and etiology of benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS).
The Prostate - 1 Aug 2017
Na Rong, Helfand Brian T, Chen Haitao, Conran Carly A, Crawford Susan E, Hayward Simon W, Tammela Teuvo L J, Hoffman-Bolton Judy, Zheng Siqun L, Walsh Patrick C, Schleutker Johanna, Platz Elizabeth A, Isaacs William B, Xu Jianfeng
Abstract excerpt
BACKGROUND: Benign prostatic hyperplasia (BPH) and associated lower urinary tract symptoms (LUTS) are common conditions. Little is known about their etiologies except that studies have suggested a substantial heritable component. Our objective is to provide a comprehensive, genome-wide evaluation of inherited risks and possible mechanisms of etiology in BPH. METHODS: We performed a three-stage, genome-wide...
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