Article
Germline BRCA2 mutations detected in pediatric sequencing studies impact parents' evaluation and care.
Cold Spring Harbor molecular case studies - 1 Nov 2017
Walsh Michael F, Kennedy Jennifer, Harlan Megan, Kentsis Alex, Shukla Neerav, Musinsky Jacob, Roberts Stephen, Kung Andrew L, Robson Mark, Kushner Brian H, Meyers Paul, Offit Kenneth
Abstract excerpt
There has been no indication to test for BRCA1/2 in children (with the rare exception of Fanconi anemia) as screening begins in adult years and there is a potential to induce anxiety related to adult-onset cancers. However, in the setting of pediatric cancer, with increasing utility and frequency of companion tumor-normal sequencing without regard for phenotype and with BRCA1/2 included in tumor profiling panels,...
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