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Article

Emerging roles of protein disulfide isomerase in cancer

31 Aug 2017

Abstract excerpt

The protein disulfide isomerase (PDI) family is a group of multifunctional endoplasmic reticulum (ER) enzymes that mediate the formation of disulfide bonds, catalyze the cysteine-based redox reactions and assist the quality control of client proteins. Recent structural and functional studies have demonstrated that PDI members not only play an essential role in the proteostasis in the ER but also exert diverse...

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PMID: 28648146
DOI: 10.5483/bmbrep.2017.50.8.107

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