Article
Activation of cytolytic T lymphocyte and natural killer cell function through the T11 sheep erythrocyte binding protein.
Nature - 1 Jan 2000
Siliciano R F, Pratt J C, Schmidt R E, Ritz J, Reinherz E L
Abstract excerpt
The T11 sheep erythrocyte binding glycoprotein [relative molecular mass (Mr)50,000(50K)] is expressed throughout human T-lymphocyte ontogeny and appears to play an important physiological role in T-cell activation. Thus, the treatment of T cells with certain monoclonal anti-T11 antibodies results...
Topics
- Animals
- Antibodies, Monoclonal
- CD2 Antigens
- Carrier Proteins
- Cell Division
- Centrifugation, Density Gradient
- Humans
- Killer Cells, Natural
- Molecular Weight
- Phenotype
- Receptors, Antigen, T-Cell
- Receptors, Immunologic
- Receptors, Interleukin-2
- Sheep
- T-Lymphocytes, Cytotoxic