Individual outcome prediction for myelodysplastic syndrome (MDS) and secondary acute myeloid leukemia from MDS after allogeneic hematopoietic cell transplantation.

doi:10.1007/s00277-017-3027-5

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Article

Individual outcome prediction for myelodysplastic syndrome (MDS) and secondary acute myeloid leukemia from MDS after allogeneic hematopoietic cell transplantation.

Annals of hematology - 1 Aug 2017

Heuser Michael, Gabdoulline Razif, Löffeld Patrick, Dobbernack Vera, Kreimeyer Henriette, Pankratz Mira, Flintrop Madita, Liebich Alessandro, Klesse Sabrina, Panagiota Victoria, Stadler Michael, Wichmann Martin, Shahswar Rabia, Platzbecker Uwe, Thiede Christian, Schroeder Thomas, Kobbe Guido, Geffers Robert, Schlegelberger Brigitte, Göhring Gudrun, Kreipe Hans-Heinrich, Germing Ulrich, Ganser Arnold, Kröger Nicolaus, Koenecke Christian, Thol Felicitas

Abstract excerpt

We integrated molecular data with available prognostic factors in patients undergoing allogeneic hematopoietic cell transplantation (alloHCT) for myelodysplastic syndrome (MDS) or secondary acute myeloid leukemia (sAML) from MDS to evaluate their impact on prognosis. Three hundred four patients were sequenced for mutations in 54 genes. We used a Cox multivariate model and competing risk analysis with internal and...

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PMID: 28612220
DOI: 10.1007/s00277-017-3027-5
PMCID: PMC7116654

Genes

NRAS
NRM
IDH1
IDH2

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