Incorporation of mutations in five genes in the revised International Prognostic Scoring System can improve risk stratification in the patients with myelodysplastic syndrome.

doi:10.1038/s41408-018-0074-7

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Article

Incorporation of mutations in five genes in the revised International Prognostic Scoring System can improve risk stratification in the patients with myelodysplastic syndrome.

Blood cancer journal - 4 Apr 2018

Hou Hsin-An, Tsai Xavier Cheng-Hong, Lin Chien-Chin, Chou Wen-Chien, Kuo Yuan-Yeh, Liu Chieh-Yu, Tseng Mei-Hsuan, Peng Yen-Ling, Liu Ming-Chih, Liu Chia-Wen, Liao Xiu-Wen, Lin Liang-In, Yao Ming, Tang Jih-Luh, Tien Hwei-Fang

Abstract excerpt

Gene mutations have not yet been included in the 2016 WHO classification and revised International Prognostic Scoring System (IPSS-R), which are now widely utilized to discriminate myelodysplastic syndrome (MDS) patients regarding risk of leukemia evolution and overall survival (OS). In this study, we aimed to investigate whether integration of gene mutations with other risk factors could further improve the...

Topics

Adolescent
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor
Female
Genetic Association Studies
Genetic Predisposition to Disease
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Kaplan-Meier Estimate

Male

Middle Aged

Mutation

Myelodysplastic Syndromes

Prognosis

Proportional Hazards Models

Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 29618722
DOI: 10.1038/s41408-018-0074-7
PMCID: PMC5884776

Genes

ASXL1
CBL
DNMT3A
IDH2
TP53

Provenance

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