Article
Clinical outcomes of platinum-based chemotherapy according to T790M mutation status in EGFR-positive non-small cell lung cancer patients after initial EGFR-TKI failure.
Lung cancer (Amsterdam, Netherlands) - 1 Jul 2017
Yoshida Tatsuya, Kuroda Hiroaki, Oya Yuko, Shimizu Junichi, Horio Yoshitsugu, Sakao Yukinori, Hida Toyoaki, Yatabe Yasushi
Abstract excerpt
BACKGROUND: Emergence of the T790M point mutation in exon 20 of epidermal growth factor receptor (EGFR) is the most common mechanism of resistance to EGFR tyrosine kinase inhibitors (EGFR-TKIs). It remains unclear whether the efficacy of platinum-doublet chemotherapy is impacted by the presence of the T790M mutation. The aim of this study is to evaluate the efficacy of platinum-doublet chemotherapy after initial...
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