Article
Decreased emergence of HIV-1 drug resistance mutations in a cohort of Ugandan women initiating option B+ for PMTCT.
PloS one - 1 Jan 2017
Machnowska Patrycja, Hauser Andrea, Meixenberger Karolin, Altmann Britta, Bannert Norbert, Rempis Eva, Schnack Alexandra, Decker Sarah, Braun Vera, Busingye Priscilla, Rubaihayo John, Harms Gundel, Theuring Stefanie
Abstract excerpt
BACKGROUND: Since 2012, WHO guidelines for the prevention of mother-to-child transmission (PMTCT) of HIV-1 in resource-limited settings recommend the initiation of lifelong antiretroviral combination therapy (cART) for all pregnant HIV-1 positive women independent of CD4 count and WHO clinical stage (Option B+). However, long-term outcomes regarding development of drug resistance are lacking until now. Therefore,...
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