Article
The B-cell receptor controls fitness of MYC-driven lymphoma cells via GSK3β inhibition.
Nature - 8 Jun 2017
Varano Gabriele, Raffel Simon, Sormani Martina, Zanardi Federica, Lonardi Silvia, Zasada Christin, Perucho Laura, Petrocelli Valentina, Haake Andrea, Lee Albert K, Bugatti Mattia, Paul Ulrike, Van Anken Eelco, Pasqualucci Laura, Rabadan Raul, Siebert Reiner, Kempa Stefan, Ponzoni Maurilio, Facchetti Fabio, Rajewsky Klaus, Casola Stefano
Abstract excerpt
Similar to resting mature B cells, where the B-cell antigen receptor (BCR) controls cellular survival, surface BCR expression is conserved in most mature B-cell lymphomas. The identification of activating BCR mutations and the growth disadvantage upon BCR knockdown of cells of certain lymphoma entities has led to the view that BCR signalling is required for tumour cell survival. Consequently, the BCR signalling...
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