Article
Connexin 43 and Mitochondria in Cardiovascular Health and Disease.
Advances in experimental medicine and biology - 1 Jan 2017
Boengler Kerstin, Schulz Rainer
Abstract excerpt
Connexin 43 (Cx43) is the major connexin protein in ventricular cardiomyocytes. Six Cx43 proteins assemble into so-called hemichannels at the sarcolemma and opposing hemichannels form gap junctions, which allow the passage of small molecules and electrical current flow between adjacent cells. Apart from its localization at the plasma membrane, Cx43 is also present in cardiomyocyte mitochondria, where it is...
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