POU4F3 mutation screening in Japanese hearing loss patients: Massively parallel DNA sequencing-based analysis identified novel variants associated with autosomal dominant hearing loss

Abstract excerpt

A variant in a transcription factor gene, POU4F3, is responsible for autosomal dominant nonsyndromic hereditary hearing loss, DFNA15. To date, 14 variants, including a whole deletion of POU4F3, have been reported to cause HL in various ethnic groups. In the present study, genetic screening for POU4F3 variants was carried out for a large series of Japanese hearing loss (HL) patients to clarify the prevalence and...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Ear Surgery and Otitis Media
• Share to Hearing, Cochlea, Tinnitus, Genetics
• Share to Vestibular and auditory disorders