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Article

The structural basis of a high affinity ATP binding ε subunit from a bacterial ATP synthase.

PloS one - 1 Jan 2017

Krah Alexander, Kato-Yamada Yasuyuki, Takada Shoji

Abstract excerpt

The ε subunit from bacterial ATP synthases functions as an ATP sensor, preventing ATPase activity when the ATP concentration in bacterial cells crosses a certain threshold. The R103A/R115A double mutant of the ε subunit from thermophilic Bacillus PS3 has been shown to bind ATP two orders of magnitude stronger than the wild type protein. We use molecular dynamics simulations and free energy calculations to derive...

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Identifiers

PMID: 28542497
DOI: 10.1371/journal.pone.0177907
PMCID: PMC5436830

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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