Article
The effect of rapamycin, NVP-BEZ235, aspirin, and metformin on PI3K/AKT/mTOR signaling pathway of PIK3CA-related overgrowth spectrum (PROS).
Oncotarget - 11 Jul 2017
Suzuki Yasuyo, Enokido Yasushi, Yamada Kenichiro, Inaba Mie, Kuwata Kumiko, Hanada Naoki, Morishita Tsuyoshi, Mizuno Seiji, Wakamatsu Nobuaki
Abstract excerpt
The phosphatidylinositol 3-kinase (PI3K)/AKT/mTOR signaling pathway is critical for cellular growth and metabolism. Recently, mosaic or segmental overgrowth, a clinical condition caused by heterozygous somatic activating mutations in PIK3CA, was established as PIK3CA-related overgrowth spectrum (PROS). In this study, we report a Japanese female diagnosed with PROS, who presented with hyperplasia of the lower...
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