Article
Laboratory Mice Are Frequently Colonized with Staphylococcus aureus and Mount a Systemic Immune Response-Note of Caution for In vivo Infection Experiments.
Frontiers in cellular and infection microbiology - 1 Jan 2017
Schulz Daniel, Grumann Dorothee, Trübe Patricia, Pritchett-Corning Kathleen, Johnson Sarah, Reppschläger Kevin, Gumz Janine, Sundaramoorthy Nandakumar, Michalik Stephan, Berg Sabine, van den Brandt Jens, Fister Richard, Monecke Stefan, Uy Benedict, Schmidt Frank, Bröker Barbara M, Wiles Siouxsie, Holtfreter Silva
Abstract excerpt
Whether mice are an appropriate model for S. aureus infection and vaccination studies is a matter of debate, because they are not considered as natural hosts of S. aureus. We previously identified a mouse-adapted S. aureus strain, which caused infections in laboratory mice. This raised the question whether laboratory mice are commonly colonized with S. aureus and whether this might impact on infection...
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