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HIV-1 CRF07_BC with a Seven Amino Acid Deletion in the gag p6 Region Dominates in HIV-1-Infected Men Who Have Sex with Men in China.

AIDS research and human retroviruses - 1 Sept 2017

Wu Yue, Wang Haiying, Ren Xuqi, Wan Zhengwei, Hu Guifang, Tang Shixing

Abstract excerpt

We examined sequence variation in the HIV-1 gag p6 region from 27 individuals infected with HIV-1 CRF07_BC. An additional 269 gag p6 sequences of CRF07_BC from the Los Alamos National Laboratory database were also analyzed. A unique deletion of seven amino acid (aa) (p6Δ7) (aa 30-36, PIDKELY, in the HXB2 genome) was observed to exist exclusively in CRF07_BC. Indeed, 54.1% (160/296) of the CRF07_BC sequences...

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PMID: 28509569
DOI: 10.1089/aid.2017.0075

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