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Article

Association between TPO Asn698Thr and Thr725Pro gene polymorphisms and serum anti-TPO levels in Iranian patients with subclinical hypothyroidism.

Hormones (Athens, Greece) - 1 Jan 2017

Khoshi Amirhosein, Sirghani Alireza, Ghazisaeedi Mehran, Mahmudabadi Ali Zarei, Azimian Amir

Abstract excerpt

OBJECTIVE: Subclinical hypothyroidism (SCH) is defined as high levels of TSH in the presence of normal levels of serum FT4. Since thyroid peroxidase (TPO) plays a key role in thyroid hormone synthesis, variations in the TPO gene can change the enzyme structure and result in the production of anti-TPO antibodies. The aim of this study was to examine the relationship between the Asn698Thr (A2095C) and Thr725Pro...

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Identifiers

PMID: 28500830
DOI: 10.14310/horm.2002.1721

Genes

TPO

Variants

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