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Article

Copy number variation of functional RBMY1 is associated with sperm motility: an azoospermia factor-linked candidate for asthenozoospermia.

Human reproduction (Oxford, England) - 1 Jul 2017

Yan Yuanlong, Yang Xiling, Liu Yunqiang, Shen Ying, Tu Wenling, Dong Qiang, Yang Dong, Ma Yongyi, Yang Yuan

Abstract excerpt

STUDY QUESTION: What is the influence of copy number variation (CNV) in functional RNA binding motif protein Y-linked family 1 (RBMY1) on spermatogenic phenotypes? SUMMARY ANSWER: The RBMY1 functional copy dosage is positively correlated with sperm motility, and dosage insufficiency is an independent risk factor for asthenozoospermia. WHAT IS KNOWN ALREADY: RBMY1, a multi-copy gene expressed exclusively in the...

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PMID: 28498920
DOI: 10.1093/humrep/dex100

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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