PI3K-Akt-mTOR axis sustains rotavirus infection via the 4E-BP1 mediated autophagy pathway and represents an antiviral target

Abstract excerpt

Rotavirus infection is a major cause of severe dehydrating diarrhea in infants younger than 5 y old and in particular cases of immunocompromised patients irrespective to the age of the patients. Although vaccines have been developed, antiviral therapy is an important complement that cannot be substituted. Because of the lack of specific approved treatment, it is urgent to facilitate the cascade of further...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Plant Virus Research Studies
• Share to Viral gastroenteritis research and epidemiology
• Share to Virus-based gene therapy research