Article
Two alternate strategies for innate immunity to Epstein-Barr virus: One using NK cells and the other NK cells and γδ T cells.
The Journal of experimental medicine - 5 Jun 2017
Djaoud Zakia, Guethlein Lisbeth A, Horowitz Amir, Azzi Tarik, Nemat-Gorgani Neda, Olive Daniel, Nadal David, Norman Paul J, Münz Christian, Parham Peter
Abstract excerpt
Most humans become infected with Epstein-Barr virus (EBV), which then persists for life. Infrequently, EBV infection causes infectious mononucleosis (IM) or Burkitt lymphoma (BL). Type I EBV infection, particularly type I BL, stimulates strong responses of innate immune cells. Humans respond to EBV in two alternative ways. Of 24 individuals studied, 13 made strong NK and γδ T cell responses, whereas 11 made...
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