Article
Exploring a causal role of DNA methylation in the relationship between maternal vitamin B12 during pregnancy and child's IQ at age 8, cognitive performance and educational attainment: a two-step Mendelian randomization study.
Human molecular genetics - 1 Aug 2017
Caramaschi Doretta, Sharp Gemma C, Nohr Ellen A, Berryman Katie, Lewis Sarah J, Davey Smith George, Relton Caroline L
Abstract excerpt
An adequate intake of vitamin B12 during pregnancy plays an important role in offspring neurodevelopment, potentially via epigenetic processes. We used a two-step Mendelian randomization approach to assess whether DNA methylation plays a mediating and causal role in associations between maternal vitamin B12 status and offspring's cognition. Firstly, we estimated the causal effect of maternal vitamin B12 levels on...
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