Article
Thymus neuroendocrine tumors with CTNNB1 gene mutations, disarrayed ß-catenin expression, and dual intra-tumor Ki-67 labeling index compartmentalization challenge the concept of secondary high-grade neuroendocrine tumor: a paradigm shift.
Virchows Archiv : an international journal of pathology - 1 Jul 2017
Fabbri Alessandra, Cossa Mara, Sonzogni Angelica, Bidoli Paolo, Canova Stefania, Cortinovis Diego, Abbate Maria Ida, Calabrese Fiorella, Nannini Nazarena, Lunardi Francesca, Rossi Giulio, La Rosa Stefano, Capella Carlo, Tamborini Elena, Perrone Federica, Busico Adele, Capone Iolanda, Valeri Barbara, Pastorino Ugo, Albini Adriana, Pelosi Giuseppe
Abstract excerpt
We herein report an uncommon association of intimately admixed atypical carcinoid (AC) and large cell neuroendocrine (NE) carcinoma (LCNEC) of the thymus, occurring in two 20- and 39-year-old Caucasian males. Both tumors were treated by maximal thymectomy. The younger patient presented with a synchronous lesion and died of disease after 9 months, while the other patient was associated with a recurrent ectopic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.