Article
Total Chemical Synthesis and Folding of All-l and All-d Variants of Oncogenic KRas(G12V).
Journal of the American Chemical Society - 7 Jun 2017
Levinson Adam M, McGee John H, Roberts Andrew G, Creech Gardner S, Wang Ting, Peterson Michael T, Hendrickson Ronald C, Verdine Gregory L, Danishefsky Samuel J
Abstract excerpt
The Ras proteins are essential GTPases involved in the regulation of cell proliferation and survival. Mutated oncogenic forms of Ras alter effector binding and innate GTPase activity, leading to deregulation of downstream signal transduction. Mutated forms of Ras are involved in approximately 30% of human cancers. Despite decades of effort to develop direct Ras inhibitors, Ras has long been considered...
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