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A gene-environment interaction analysis of plasma selenium with prevalent and incident diabetes: The Hortega study.

Redox biology - 1 Aug 2017

Galan-Chilet Inmaculada, Grau-Perez Maria, De Marco Griselda, Guallar Eliseo, Martin-Escudero Juan Carlos, Dominguez-Lucas Alejandro, Gonzalez-Manzano Isabel, Lopez-Izquierdo Raul, Briongos-Figuero Laisa Socorro, Redon Josep, Chaves Felipe Javier, Tellez-Plaza Maria

Abstract excerpt

BACKGROUND: Selenium and single-nucleotide-polymorphisms in selenoprotein genes have been associated to diabetes. However, the interaction of selenium with genetic variation in diabetes and oxidative stress-related genes has not been evaluated as a potential determinant of diabetes risk. METHODS: We evaluated the cross-sectional and prospective associations of plasma selenium concentrations with type 2 diabetes,...

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Identifiers

PMID: 28437656
DOI: 10.1016/j.redox.2017.04.022
PMCID: PMC5403796

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