Article
A novel device for continuous long-term electroencephalogram recording and drug administration in mice with a nice, powerful and sophisticated wired system.
Journal of neuroscience methods - 15 Jul 2017
Watanabe Shigeru, Saito Masanori, Soma Masaki, Miyaoka Hitoshi, Takahashi Masami
Abstract excerpt
BACKGROUND: To elucidate mechanisms of epileptogenesis and epileptic maturation, and to develop new AEDs, it is indispensable to administer various drugs and to examine their effects on EEG over a long period of observation. NEW METHOD: We constructed a device for the continuous measurement of electroencephalography (EEG) and the infusion of anti-epileptic drugs over a prolonged period of time in moving mice. The...
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