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Targeting on poly(ADP-ribose) polymerase activity with DNA-damaging hybrid lactam-steroid alkylators in wild-type and BRCA1-mutated ovarian cancer cells.

Chemical biology & drug design - 1 Nov 2017

Trafalis Dimitrios T, Polonifi Aikaterini, Dalezis Panayiotis, Nikoleousakos Nikolaos, Katsamakas Sotirios, Sarli Vasiliki

Abstract excerpt

Conjugated lactam-steroid alkylators (LSA) have been shown to exhibit superior activity at controlling cancer models and overlap drug resistance to conventional chemjournalapy. Hybrid LSA combine two active compounds in a single molecule and incorporate modified steroids bearing lactam moiety in one or more steroid rings functioning as vectors for cytotoxic agents. We first describe a novel class of LSA that...

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Identifiers

PMID: 28432813
DOI: 10.1111/cbdd.13006

Genes

BRCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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