Article
Involvement of AF1q/MLLT11 in the progression of ovarian cancer.
Oncotarget - 4 Apr 2017
Tiberio Paola, Lozneanu Ludmila, Angeloni Valentina, Cavadini Elena, Pinciroli Patrizia, Callari Maurizio, Carcangiu Maria Luisa, Lorusso Domenica, Raspagliesi Francesco, Pala Valentina, Daidone Maria Grazia, Appierto Valentina
Abstract excerpt
The functional role of AF1q/MLLT11, an oncogenic factor involved in a translocation t(1;11)(q21;q23) responsible for acute myeloid leukaemia, has been investigated in hematological and solid malignancies and its expression was found to be linked to tumor progression and poor clinical outcome. In addition to its oncogenic function, AF1q has been shown to play a role in the onset of basal and drug-induced apoptosis...
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